The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene

Item Type:	Article
Title:	The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene
Creators Name:	Bégay-Müller, V. and Ansieau, S. and Leutz, A.
Abstract:	The LIM only protein Lmo2 plays an important role in hematopoiesis and leukemogenesis. Lmo2 acts as a bridging molecule between components of hematopoietic gene regulatory protein complexes. We used the yeast two-hybrid system to identify novel Lmo2 interacting proteins and found that the AF6 protein binds to Lmo2. AF6 is a recurrent fusion partner of MLL, the human homolog of Drosophila trithorax chromatin remodeling protein that is involved in childhood leukemia and mixed lineage leukemia. Our data support the notion that recurrent fusion partners of chimeric MLL proteins recruit hematopoietic gene regulatory complexes.
Keywords:	Epigenetic, Trithorax, Leukemia, Gene Regulation, Hematopoiesis, Animals, Drosophila, Quail
Source:	FEBS Letters
ISSN:	0014-5793
Publisher:	Elsevier
Volume:	521
Number:	1-3
Page Range:	36-38
Date:	19 June 2002
Official Publication:	https://doi.org/10.1016/S0014-5793(02)02814-4
PubMed:	View item in PubMed

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