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Chemokine requirements for B cell entry to lymph nodes and Peyers patches

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Official URL:https://doi.org/10.1084/jem.20020201
PubMed:View item in PubMed
Creators Name:Okada, T. and Ngo, V.N. and Ekland, E.H. and Foerster, R. and Lipp, M. and Littman, D.R. and Cyster, J.G.
Journal Title:Journal of Experimental Medicine
Journal Abbreviation:J Exp Med
Volume:196
Number:1
Page Range:65-75
Date:1 July 2002
Keywords:Chemokine, High Endothelial Venule, Adhesion, Lymphoid Organ, B Cell, Animals, Mice
Abstract:B cell entry to lymph nodes and Peyer's patches depends on chemokine receptor signaling, but the principal chemokine involved has not been defined. Here we show that the homing of CXCR4-/- B cells is suppressed in CCL19 (ELC)- and CCL21 (SLC)-deficient paucity of lymph node T cells mice, but not in wild-type mice. We also find that CXCR4 can contribute to T cell homing. Using intravital microscopy, we find that B cell adhesion to high endothelial venules (HEVs) is disrupted when CCR7 and CXCR4 are predesensitized. In Peyer's patches, B cell entry is dependent on CXCR5 in addition to CCR7/CXCR4. CXCL12 (SDF1) is displayed broadly on HEVs, whereas CXCL13 (BLC) is found selectively on Peyer's patch follicular HEVs. These findings establish the principal chemokine and chemokine receptor requirements for B cell entry to lymph nodes and Peyer's patches.
ISSN:0022-1007
Publisher:Rockefeller University Press (U.S.A.)
Item Type:Article

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