Calcium entry through kainate receptors and resulting potassium- channel blockade in Bergmann glial cells

Item Type:	Article
Title:	Calcium entry through kainate receptors and resulting potassium- channel blockade in Bergmann glial cells
Creators Name:	Mueller, T. and Moeller, T. and Berger, T. and Schnitzer-Ungefug, J. and Kettenmann, H.
Abstract:	Glutamate receptors, the most abundant excitatory transmitter receptors in the brain, are not restricted to neurons; they have also been detected on glial cells. Bergmann glial cells in mouse cerebellar slices revealed a kainate-type glutamate receptor with a sigmoid current-to-voltage relation, as demonstrated with the patch-clamp technique. Calcium was imaged with fura-2, and a kainate-induced increase in intracellular calcium concentration was observed, which was blocked by the non-N-methyl-D-aspartate (NMDA) glutamate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and by low concentrations of external calcium, indicating that there was an influx of calcium through the kainate receptor itself. The entry of calcium led to a marked reduction in the resting (passive) potassium conductance of the cell. Purkinje cells, which have glutamatergic synapses, are closely associated with Bergmann glial cells and therefore may provide a functionally important stimulus.
Keywords:	Biological Transport, Calcium, Cerebellum, Electric Conductivity, Ion Channel Gating, Ionomycin, Kainic Acid, Neuroglia, Potassium Channels, Kainic Acid Receptors, Neurotransmitter Receptors, Animals, Mice
Source:	Science
ISSN:	0036-8075
Publisher:	American Association for the Advancement of Science
Volume:	256
Number:	5063
Page Range:	1563-1566
Date:	12 June 1992
Official Publication:	https://doi.org/10.1126/science.1317969
PubMed:	View item in PubMed

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