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Angiotensin blockade prevents type 2 diabetes by formation of fat cells

Item Type:Article
Title:Angiotensin blockade prevents type 2 diabetes by formation of fat cells
Creators Name:Sharma, A.M. and Janke, E. and Gorzelniak, K. and Engeli, S. and Luft, F.C.
Abstract:Obesity is the prime risk factor for the development of type 2 diabetes. Recent clinical trials have shown that blockade of the renin-angiotensin system, either by inhibiting the angiotensin-converting enzyme or blocking the angiotensin type 1 receptor, may substantially lower the risk for type 2 diabetes. The mechanism underlying this effect is unknown. Based on our recent observation that angiotensin II markedly inhibits adipogenic differentiation of human adipocytes via the angiotensin type I receptor and that expression of angiotensin II–forming enzymes in adipose tissue is inversely correlated with insulin sensitivity, we propose the hypothesis that blockade of the renin-angiotensin system prevents diabetes by promoting the recruitment and differentiation of adipocytes. Increased formation of adipocytes would counteract the ectopic deposition of lipids in other tissues (muscle, liver, pancreas), thereby improving insulin sensitivity and preventing the development of type 2 diabetes.
Keywords:Angiotensin, Diabetes, Adipose Tissue, Insulin Resistance, Obesity, Animals
Source:Hypertension
ISSN:0194-911X
Publisher:American Heart Association (U.S.A.)
Volume:40
Number:5
Page Range:609-611
Date:1 November 2002
Official Publication:https://doi.org/10.1161/01.HYP.0000036448.44066.53
PubMed:View item in PubMed

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