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Resistin gene expression in human adipocytes is not related to insulin resistance

Item Type:Article
Title:Resistin gene expression in human adipocytes is not related to insulin resistance
Creators Name:Janke, J. and Engeli, S. and Gorzelniak, K. and Luft, F.C. and Sharma, A.M.
Abstract:Objectives: Obesity is an important risk factor for the development of insulin resistance and type 2 diabetes. Recently, a newly described circulating hormone resistin, which is expressed primarily in adipocytes, has been shown to antagonize insulin action in mice. Resistin, therefore, has been suggested to play a role in the pathogenesis of insulin resistance. Research Methods and Procedures: We studied the expression of the resistin gene in primary cultured human adipocytes and preadipocytes. We also examined resistin gene expression in subcutaneous abdominal adipocytes in women (n = 24) over a wide range of body weight and insulin sensitivity. Results: Whereas resistin gene expression was barely detectable in mature adipocytes, it was highly expressed in preadipocytes. Adipogenic differentiation of preadipocytes was associated with a time-dependent down-regulation of resistin gene expression. There was no relationship between body weight, insulin sensitivity, or other metabolic parameters and adipocyte resistin gene expression in the clinical study. Discussion: Together these findings do not support an important role of adipose-tissue resistin gene expression in human insulin resistance.
Keywords:Resistin, Adipocytes, Adipogenesis, Insulin Resistance
Source:Obesity Research
ISSN:1071-7323
Publisher:North Amer Assoc Study Obessity (U.S.A.)
Volume:10
Number:1
Page Range:1-5
Date:January 2002
Official Publication:https://doi.org/10.1038/oby.2002.1
PubMed:View item in PubMed

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