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Inversions and the dynamics of eukaryotic gene order

Item Type:Article
Title:Inversions and the dynamics of eukaryotic gene order
Creators Name:Huynen, M.A. and Snel, B. and Bork, P.
Abstract:Comparisons of the gene order in closely related genomes reveal a major role for inversions in the genome shuffling process. In contrast to prokaryotes, where the inversions are predominantly large, half of the inversions between Saccharomyces cerevisiae and Candida albicans appear to be small, often encompassing only a single gene. Overall the genome rearrangement rate appears higher in eukaryotes than in prokaryotes, and the current genome data do not indicate that functional constraints on the co-expression of neighboring genes have a large role in conserving eukaryotic gene order. Nevertheless, qualitatively interesting examples of conservation of gene order in eukaryotes can be observed.
Keywords:Bacterial Genome, Candida albicans, Chromosome Inversion, Escherichia coli, Fungal Genome, Gene Rearrangement, Haemophilus influenzae, Operon, Saccharomyces cerevisiae
Source:Trends in Genetics
Publisher:Elsevier (The Netherlands)
Page Range:304-306
Date:1 June 2001
Official Publication:https://doi.org/10.1016/S0168-9525(01)02302-2
PubMed:View item in PubMed

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