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A large gene cluster encoding several magnetosome proteins is conserved in different species of magnetotactic bacteria

Item Type:Article
Title:A large gene cluster encoding several magnetosome proteins is conserved in different species of magnetotactic bacteria
Creators Name:Gruenberg, K. and Wawer, C. and Tebo, B.M. and Schueler, D.
Abstract:In magnetotactic bacteria, a number of specific proteins are associated with the magnetosome membrane (MM) and may have a crucial role in magnetite biomineralization. We have cloned and sequenced the genes of several of these polypeptides in the magnetotactic bacterium Magnetospirillum gryphiswaldense that could be assigned to two different genomic regions. Except for mamA, none of these genes have been previously reported to be related to magnetosome formation. Homologous genes were found in the genome sequences ofM. magnetotacticum and magnetic coccus strain MC-1. The MM proteins identified display homology to tetratricopeptide repeat proteins (MamA), cation diffusion facilitators (MamB), and HtrA-like serine proteases (MamE) or bear no similarity to known proteins (MamC and MamD). A major gene cluster containing several magnetosome genes (including mamA and mamB) was found to be conserved in all three of the strains investigated. ThemamAB cluster also contains additional genes that have no known homologs in any nonmagnetic organism, suggesting a specific role in magnetosome formation.
Keywords:Amino Acid Sequence, Bacterial Genes, Bacterial Genome, Bacterial Proteins, Conserved Sequence, DNA Sequence Analysis, Ferrosoferric Oxide, Iron, Magnetics, Molecular Cloning, Molecular Sequence Data, Multigene Family, Organelles, Oxides, Rhodospirillaceae
Source:Applied and Environmental Microbiology
ISSN:0099-2240
Publisher:American Society for Microbiology (U.S.A.)
Volume:67
Number:10
Page Range:4573-4582
Date:October 2001
Official Publication:https://doi.org/10.1128/AEM.67.10.4573-4582.2001
PubMed:View item in PubMed

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