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Chicken acidic leucine-rich EGF-like domain containing brain protein (CALEB), a neural member of the EGF family of differentiation factors, is implicated in neurite formation

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Item Type:Article
Title:Chicken acidic leucine-rich EGF-like domain containing brain protein (CALEB), a neural member of the EGF family of differentiation factors, is implicated in neurite formation
Creators Name:Schumacher, S. and Volkmer, H. and Buck, F. and Otto, A. and Tarnok, A. and Roth, S. and Rathjen, F.G.
Abstract:Chicken acidic leucine-rich EGF-like domain containing brain protein (CALEB) was identified by combining binding assays with immunological screens in the chicken nervous system as a novel member of the EGF family of differentiation factors. cDNA cloning indicates that CALEB is a multidomain protein that consists of an NH(2)-terminal glycosylation region, a leucine-proline-rich segment, an acidic box, a single EGF-like domain, a transmembrane, and a short cytoplasmic stretch. In the developing nervous system, CALEB is associated with glial and neuronal surfaces. CALEB is composed of a 140/130-kD doublet, an 80-kD band, and a chondroitinsulfate-containing 200-kD component. The latter two components are expressed in the embryonic nervous system and are downregulated in the adult nervous system. CALEB binds to the extracellular matrix glycoproteins tenascin-C and -R. In vitro antibody perturbation experiments reveal a participation of CALEB in neurite formation in a permissive environment.
Keywords:Amino Acid Sequence, Antigen Receptors, Avian Proteins, Axons, Blocking Antibodies, Brain Chemistry, Cell Adhesion Molecules, Cell Membrane, Chick Embryo, Chondroitin Sulfates, Epidermal Growth Factor, Leucine, Membrane Glycoproteins, Molecular Sequence Data, Nerve Tissue Proteins, Neurites, Neuroglia, Neuronal Cell Adhesion Molecules, Neurons, Retina, Substrate Specificity, Tenascin, Animals, Chickens
Source:Journal of Cell Biology
ISSN:0021-9525
Publisher:Rockefeller University Press (U.S.A.)
Volume:136
Number:4
Page Range:895-906
Date:24 February 1997
Additional Information:Copyright (c) 1997 by The Rockefeller University Press
Official Publication:https://doi.org/10.1083/jcb.136.4.895
PubMed:View item in PubMed

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