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The homeodomain factor Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord

Official URL:https://doi.org/10.1016/S0896-6273(02)00689-X
PubMed:View item in PubMed
Creators Name:Mueller, T. and Brohmann, H. and Pierani, A. and Heppenstall, P.A. and Lewin, G.R. and Jessell, T.M. and Birchmeier, C.
Journal Title:Neuron
Journal Abbreviation:Neuron
Volume:34
Number:4
Page Range:551-562
Date:16 May 2002
Keywords:Afferent Pathways, Avian Proteins, Axons, Basic Helix-Loop-Helix Transcription Factors, Body Patterning, Cell Differentiation, Cell Lineage, Chick Embryo, Developmental Gene Expression Regulation, DNA-Binding Proteins, Genetically Modified Animals, Homeodomain Proteins, Mitosis, Muscle Proteins, Mutation, Mutant Strains Mice, Nervous System Malformations, PAX7 Transcription Factor, Posterior Horn Cells, Spinal Nerve Roots, Stem Cells, Transcription Factors, Animals, Mice
Abstract:Dorsal horn neurons in the spinal cord integrate and relay sensory information. Here, we show that the expression of the homeobox gene Lbx1 distinguishes two major neuronal classes generated in the dorsal spinal cord. The Lbx1 - (class A) and Lbx1 + (class B) neurons differ in their dependence on roof plate BMP signals for specification and settle in the deep and superficial dorsal horn, respectively. Lbx1 misexpression blocks the differentiation of class A neurons. Conversely, in Lbx1 mutant mice, class B neurons assume the identity of class A neurons. As a consequence, the morphology and neuronal circuitry of the dorsal horn are aberrant. We conclude that Lbx1 distinguishes two major neuronal classes in the dorsal spinal cord and is an important determinant of their distinct differentiation programs.
ISSN:0896-6273
Publisher:Cell Press (U.S.A.)
Item Type:Article

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