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Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin

Official URL:https://doi.org/10.1016/S0092-8674(02)00757-2
PubMed:View item in PubMed
Creators Name:Mukouyama, Y. and Shin, D. and Britsch, S. and Taniguchi, M. and Anderson, D.J.
Journal Title:Cell
Journal Abbreviation:Cell
Volume:109
Number:6
Page Range:693-705
Date:14 June 2002
Keywords:Afferent Neurons, Arteries, Cell Differentiation, Cell Movement, Endothelial Growth Factors, ErbB-3 Receptor, Extremities, Fluorescence Microscopy, Immunohistochemistry, In Situ Hybridization, Lymphokines, Mutation, Neurons, Reverse Transcriptase Polymerase Chain Reaction, Schwann Cells, Skin, Smooth Muscle, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors, Animals, Mice
Abstract:Nerves and blood vessels are branched structures, but whether their branching patterns are established independently or coordinately is not clear. Here we show that arteries, but not veins, are specifically aligned with peripheral nerves in embryonic mouse limb skin. Mutations that eliminate peripheral sensory nerves or Schwann cells prevent proper arteriogenesis, while those that disorganize the nerves maintain the alignment of arteries with misrouted axons. In vitro, sensory neurons or Schwann cells can induce arterial marker expression in isolated embryonic endothelial cells, and VEGF164/120 is necessary and sufficient to mediate this induction. These data suggest that peripheral nerves provide a template that determines the organotypic pattern of blood vessel branching and arterial differentiation in the skin, via local secretion of VEGF.
ISSN:0092-8674
Publisher:Cell Press (U.S.A.)
Item Type:Article

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