Cardenamides from cardenolides: Cardiac and anticancer activities

Item Type:	Article
Title:	Cardenamides from cardenolides: Cardiac and anticancer activities
Creators Name:	Megges, R. and Weiland, J. and Schoen, R. and Repke, H. and Repke, K.R.H.
Abstract:	Two ways are shown to transform cardioactive cardenolides into cardenamides [17{beta}-(5-oxo-2,5-dihydropyrrol-3-yl)-5{beta},14{beta}-androstane derivatives], and their derivatives by replacement of their ring oxygen by N-R. Cardioactivity is strongly decreased by this transformation. The comparatively easily accessible 21-oxocardenamides [17{beta}-(2-maleimidyl)steroids] are strongly thiol reactive and show remarkable anticancer activity.
Keywords:	Na+/K+-ATPase Inhibition, Cardenolides, Cardenamides, Steroids, Lactams, 21-Oxocardenamides, Anticancer Activity
Source:	Collection of Czechoslovak Chemical Communications
ISSN:	0010-0765
Publisher:	Institute of Organic Chemistry and Biochemistry
Volume:	67
Number:	3
Page Range:	336-352
Date:	2002
Official Publication:	https://doi.org/10.1135/cccc20020336

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