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Pentoxifylline influences drug transport activity of P-glycoprotein and decreases mdr1 gene expression in multidrug resistant mouse leukemic L1210/VCR cells

Item Type:Article
Title:Pentoxifylline influences drug transport activity of P-glycoprotein and decreases mdr1 gene expression in multidrug resistant mouse leukemic L1210/VCR cells
Creators Name:Drobna, Z. and Stein, U. and Walther, W. and Barancik, M. and Breier, A.
Abstract:The effects of pentoxifylline (PTX) on intracellular accumulation of doxorobicin (DOX), DOX cytotoxicity and expression of Pgp in multidrug resistant L1210/VCR cell line were investigated. PTX (100 mg/l) was able to enhance the DOX accumulation in resistant cells. The maximum intracellular levels of DOX were reached after treatment with PTX for 24 hours (total duration of PTX-treatment was 72 hours). The levels of mdrl mRNA (measured by RT-PCR method) were decreased 2-fold in the presence of 100 mg/l PTX (minimum reached within 48 hours) in comparison to control cells.
Keywords:Pentoxifylline, Doxorubicin, Mdr1 MRNA, P-Glycoprotein, Multidrug Resistance, Vincristine, L1210 Cells, Animals, Mice
Source:General Physiology and Biophysics
ISSN:0231-5882
Publisher:Slovak Academy of Sciences (Slovakia)
Volume:21
Number:1
Page Range:103-109
Date:March 2002
PubMed:View item in PubMed

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