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Cross-priming versus cross-tolerance: are two signals enough?

Official URL:https://doi.org/10.1016/S1471-4906(02)02185-3
PubMed:View item in PubMed
Creators Name:Blankenstein, T. and Schueler, T.
Journal Title:Trends in Immunology
Journal Abbreviation:Trends Immunol
Volume:23
Number:4
Page Range:171-173
Date:1 April 2002
Keywords:Antigen Presentation, Dendritic Cells, Immune Tolerance, Interleukins, Lymphocyte Activation, Self Tolerance, Signal Transduction, T-Lymphocyte Subsets, Animals
Abstract:Depending on their state of maturation, dendritic cells (DCs) can cross-prime or cross-tolerize T cells. Mature DCs provide T-cell-receptor ligands (signal 1) and costimulatory molecules (signal 2), and activate T cells. Immature DCs provide signal 1, but not signal 2, and tolerize T cells. However, new data show that it is not the expression of costimulatory molecules alone that determines whether DCs induce immunity or tolerance, because mature DCs can induce tolerance also.
ISSN:1471-4906
Publisher:Elsevier Sci Ltd (U.S.A.)
Item Type:Editorial

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