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Affinity maturation in ectopic germinal centers

Item Type:Article
Title:Affinity maturation in ectopic germinal centers
Creators Name:de Boer, B.A. and Voigt, I. and Kim, H.J. and Camacho, S.A. and Lipp, M. and Foerster, R. and Berek, C.
Abstract:It is becoming clear that a precisely structured lymphoid tissue is essential for the establishment of an antigen specific immune response. The differentiation of the antigen activated lymphocyte into effector cells requires a well organized microenvironment in which the antigen specific and the antigen presenting cells come into close physical contact. The central role of cytokines in lymphoid organogenesis and the important function of chemokines for guided cell movement into and within the secondary lymphoid organs are just emerging.
Keywords:Antigen-Presenting Cells, Autoimmune Diseases, B-Lymphocytes, CXCR5 Receptors, Cell Communication, Chemokine Receptors, Cytokine Receptors, Germinal Center, Spleen, T-Lymphocytes, Animals, Mice
Source:Current Topics in Microbiology and Immunology
Page Range:191-195
Official Publication:https://doi.org/10.1007/978-3-642-57276-0_24
PubMed:View item in PubMed

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