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| Item Type: | Article |
|---|---|
| Title: | Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response |
| Creators Name: | Churin, Y. and Al Ghoul, L. and Kepp, O. and Meyer, T.E. and Birchmeier, W. and Naumann, M. |
| Abstract: | Infection with the human microbial pathogen Helicobacter pylori is assumed to lead to invasive gastric cancer. We find that H. pylori activates the hepatocyte growth factor/scatter factor receptor c-Met, which is involved in invasive growth of tumor cells. The H. pylori effector protein CagA intracellularly targets the c-Met receptor and promotes cellular processes leading to a forceful motogenic response. CagA could represent a bacterial adaptor protein that associates with phospholipase C{gamma} but not Grb2-associated binder 1 or growth factor receptor-bound protein 2. The H. pylori-induced motogenic response is suppressed and blocked by the inhibition of PLC{gamma} and of MAPK, respectively. Thus, upon translocation, CagA modulates cellular functions by deregulating c-Met receptor signaling. The activation of the motogenic response in H. pylori-infected epithelial cells suggests that CagA could be involved in tumor progression. |
| Keywords: | Epithelial-Mesenchymal Transition, Hepatocyte Growth Factor, Motility, Tumor Invasion, Motogenic Response, PLC{gamma} |
| Source: | Journal of Cell Biology |
| ISSN: | 0021-9525 |
| Publisher: | Rockefeller University Press |
| Volume: | 161 |
| Number: | 2 |
| Page Range: | 249-255 |
| Date: | 28 April 2003 |
| Additional Information: | Copyright (c) 2003 by The Rockefeller University Press |
| Official Publication: | https://doi.org/10.1083/jcb.200208039 |
| PubMed: | View item in PubMed |
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