Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response

Churin, Y.; Al Ghoul, L.; Kepp, O.; Meyer, T.E.; Birchmeier, W.; Naumann, M.

Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response

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Item Type:	Article
Title:	Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response
Creators Name:	Churin, Y., Al Ghoul, L., Kepp, O., Meyer, T.E., Birchmeier, W. and Naumann, M.
Abstract:	Infection with the human microbial pathogen Helicobacter pylori is assumed to lead to invasive gastric cancer. We find that H. pylori activates the hepatocyte growth factor/scatter factor receptor c-Met, which is involved in invasive growth of tumor cells. The H. pylori effector protein CagA intracellularly targets the c-Met receptor and promotes cellular processes leading to a forceful motogenic response. CagA could represent a bacterial adaptor protein that associates with phospholipase C{gamma} but not Grb2-associated binder 1 or growth factor receptor-bound protein 2. The H. pylori-induced motogenic response is suppressed and blocked by the inhibition of PLC{gamma} and of MAPK, respectively. Thus, upon translocation, CagA modulates cellular functions by deregulating c-Met receptor signaling. The activation of the motogenic response in H. pylori-infected epithelial cells suggests that CagA could be involved in tumor progression.
Keywords:	Epithelial-Mesenchymal Transition, Hepatocyte Growth Factor, Motility, Tumor Invasion, Motogenic Response, PLC{gamma}
Source:	Journal of Cell Biology
ISSN:	0021-9525
Publisher:	Rockefeller University Press
Volume:	161
Number:	2
Page Range:	249-255
Date:	28 April 2003
Additional Information:	Copyright (c) 2003 by The Rockefeller University Press
Official Publication:	https://doi.org/10.1083/jcb.200208039
PubMed:	View item in PubMed

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