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Neurotrophins: a link between airway inflammation and airway smooth muscle contractility in asthma?

Item Type:Article
Title:Neurotrophins: a link between airway inflammation and airway smooth muscle contractility in asthma?
Creators Name:Braun, A. and Lommatzsch, M. and Lewin, G.R. and Virchow, J.C. and Renz, H.
Abstract:Background: Bronchial asthma (BA) is characterized by a unique type of airway inflammation, epithelial cell damage and increased airway smooth muscle (ASM) contractility. The regulatory network between the immunological events and the neuronal control of ASM contractility remains to be defined. Methods: Utilizing a well–characterized mouse model of airway inflammation and BA, we analyzed the production and function of neurotrophins in allergic asthma. To confirm these data in humans, segmental allergen provocation was performed in mild asthmatics. Results: Allergen–induced airway inflammation was associated with increased local production of the neurotrophins nerve growth factor (NGF) and brain–derived neurotrophic factor (BDNF) in mice as well as in humans. In bronchoalveolar lavage fluid (BALF), NGF levels were increased 4– to 5–fold in men and mice 1 day after allergen provocation. The increase in BDNF was about 2–fold in both models. Treatment of mice with anti–NGF prevented development of airway hyperresponsiveness (AHR). In the human study group, NGF levels in BALF after allergen provocation were correlated significantly with baseline FEV1 levels. Conclusion: These data strongly suggest that neurotrophins serve as a link between airway inflammation and neuronal control of ASM constriction in BA.
Keywords:Nerver Growth Factor, Brain-Derived Neurotrophic Factor, Allergy, Inflammation, Neuroimmunology, Airway, Neurotrophin, Th2 Immune Response, Airway Hyperresponsiveness, Animals, Mice
Source:International Archives of Allergy and Immunology
Page Range:163-165
Date:February 1999
Official Publication:https://doi.org/10.1159/000024056
PubMed:View item in PubMed

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