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More hippocampal neurons in adult mice living in an enriched environment

Item Type:Article
Title:More hippocampal neurons in adult mice living in an enriched environment
Creators Name:Kempermann, G. and Kuhn, H.G. and Gage, F.H.
Abstract:Neurogenesis occurs in the dentate gyrus of the hippocampus throughout the life of a rodent, but the function of these new neurons and the mechanisms that regulate their birth are unknown. Here we show that significantly more new neurons exist in the dentate gyrus of mice exposed to an enriched environment compared with littermates housed in standard cages. We also show, using unbiased stereology, that the enriched mice have a larger hippocampal granule cell layer and 15 per cent more granule cell neurons in the dentate gyrus.
Keywords:Bromodeoxyuridine, Cell Count, Cell Division, Dentate Gyrus, Environment, Animal Housing, Maze Learning, Neurons, Animals, Mice
Source:Nature
ISSN:0028-0836
Publisher:Nature Publishing Group (U.K.)
Volume:386
Number:6624
Page Range:493-495
Date:3 April 1997
Official Publication:https://doi.org/10.1038/386493a0
PubMed:View item in PubMed

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