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Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia

Item Type:Article
Title:Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia
Creators Name:Doerdelmann, M. and Reiter, A. and Borkhardt, A. and Ludwig, W.D. and Goetz, N. and Viehmann, S. and Gadner, H. and Riehm, H. and Schrappe, M.
Abstract:To define prognostic factors in infant acute lymphoblastic leukemia (ALL), the outcome of 106 infants (age ≤12 months) during 3 consecutive multicenter trials of the Berlin-Frankfurt-Muenster group (ALL-BFM 83, 86, and 90) was retrospectively analyzed according to presenting features and early in vivo response to prednisone. The prednisone response was defined as the cytoreduction (number of blood blasts per microliter at day 8) to a 7-day prednisone prephase and 1 intrathecal dose of methotrexate on day 1. Prednisone good responder (PGR; <1,000 blasts/{mu}L) received conventional therapy and prednisone poor responder (PPR; ≥1,000 blasts/{mu}L) received intensified therapy. Infant ALL was characterized by a high incidence of a white blood cell count greater than 100 × 103/{mu}L (57%), central nervous system leukemia (24%), lack of CD10 expression (59%), 11q23 rearrangement (49%) including the translocation t(4;11) (29%), and a comparatively high proportion of PPR (26%), which were all significantly associated with inferior outcome by univariate analysis. The estimated probability for an event-free survival at 6 years (pEFS) was by far better for PGR compared with PPR, who had a dismal prognosis despite intensified treatment (pEFS, 53% ± 6%v 15% ± 7%, P = .0001). Infant PGR, who were less than 6 months of age (n = 40), lacked CD10 expression (n = 43), and/or had an 11q23 rearrangement (n = 17) fared significantly better compared with corresponding PPR, as indicated by a pEFS of 44% ± 8%, 49% ± 8%, and 41% ± 12%, respectively. In multivariate analysis, PPR was the strongest adverse prognostic factor (relative risk, 3.3; 95% confidence interval, 1.9 to 5.8; P< .0001). Infants with PGR, comprising a major subgroup (74%) among infants, might successfully be treated with conventional therapy, whereas PPR require new therapeutic strategies, including early treatment intensification or bone marrow transplantation in first remission.
Keywords:Antineoplastic Combined Chemotherapy Protocols, Disease-Free Survival, Hormonal Antineoplastic Agents, Multivariate Analysis, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Predictive Value of Tests, Prednisone, Prognosis, Retrospective Studies
Publisher:American Society of Hematology
Page Range:1209-1217
Date:15 August 1999
Official Publication:http://bloodjournal.hematologylibrary.org/cgi/content/abstract/94/4/1209
PubMed:View item in PubMed

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