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Cytochrome P-450-CO and substrates: lessions from ligand binding under high pressure

Item Type:Review
Title:Cytochrome P-450-CO and substrates: lessions from ligand binding under high pressure
Creators Name:Jung, C.
Abstract:An overview of the application of high-pressure studies on the carbon monoxide complex of cytochrome P-450 is given. Different approaches to characterize ligand binding steps, the conformational states and substates and the compressibility of the ligand-bound complex are reviewed. A particular focus is the effect of substrates on these properties. It is shown that substrate mobility, compressibility and water accessibility are interrelated and may have functional meaning.
Keywords:Compressibility, Cytochrome P-450, Fourier Transform Infrared Spectroscopy, High Pressure, Ligand binding, UV-Visible Spectroscopy
Source:Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology
ISSN:0167-4838
Publisher:Elsevier Science BV (The Netherlands)
Volume:1595
Number:1-2
Page Range:309-328
Date:1 January 2002
PubMed:View item in PubMed

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