Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Interaction of urokinase-type plasminogenactivator (u-PA) with its cellular receptor (u-PAR) induces phosphorylation on tyrosine of a 38 kDa protein

Item Type:Article
Title:Interaction of urokinase-type plasminogenactivator (u-PA) with its cellular receptor (u-PAR) induces phosphorylation on tyrosine of a 38 kDa protein
Creators Name:Dumler, I. and Petri, T. and Schleuning, W.D.
Abstract:We demonstrate by immunoprecipitation that u-PAR is associated with a 38 kDa protein that is phosphorylated on tyrosine after u-PA treatment of cells. As tyrosine phosphorylation is the hallmark of many signal transduction pathways that promote growth and differentiation, these data suggest that u-PA, besides its role as a regulatory protease, might act as a para- or autocrine hormone.
Keywords:Affinity Chromatography, Polyacrylamide Gel Electrophoresis, Neoplasm Proteins, Phosphorylation, Precipitin Tests, Cell Surface Receptors, Urokinase Plasminogen Activator Receptors, Cultured Tumor Cells, Tyrosine, Urokinase-Type Plasminogen Activator
Source:FEBS Letters
ISSN:0014-5793
Publisher:Elsevier (The Netherlands)
Volume:322
Number:1
Page Range:37-40
Date:3 May 1993
Official Publication:https://doi.org/10.1016/0014-5793(93)81106-A
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library