Interaction of urokinase-type plasminogenactivator (u-PA) with its cellular receptor (u-PAR) induces phosphorylation on tyrosine of a 38 kDa protein

Item Type:	Article
Title:	Interaction of urokinase-type plasminogenactivator (u-PA) with its cellular receptor (u-PAR) induces phosphorylation on tyrosine of a 38 kDa protein
Creators Name:	Dumler, I. and Petri, T. and Schleuning, W.D.
Abstract:	We demonstrate by immunoprecipitation that u-PAR is associated with a 38 kDa protein that is phosphorylated on tyrosine after u-PA treatment of cells. As tyrosine phosphorylation is the hallmark of many signal transduction pathways that promote growth and differentiation, these data suggest that u-PA, besides its role as a regulatory protease, might act as a para- or autocrine hormone.
Keywords:	Affinity Chromatography, Polyacrylamide Gel Electrophoresis, Neoplasm Proteins, Phosphorylation, Precipitin Tests, Cell Surface Receptors, Urokinase Plasminogen Activator Receptors, Cultured Tumor Cells, Tyrosine, Urokinase-Type Plasminogen Activator
Source:	FEBS Letters
ISSN:	0014-5793
Publisher:	Elsevier
Volume:	322
Number:	1
Page Range:	37-40
Date:	3 May 1993
Official Publication:	https://doi.org/10.1016/0014-5793(93)81106-A
PubMed:	View item in PubMed

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