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Protein domain analysis in the era of complete genomes

Item Type:Review
Title:Protein domain analysis in the era of complete genomes
Creators Name:Copley, R.R. and Doerks, T. and Letunic, I. and Bork, P.
Abstract:Domains present one of the most useful levels at which to understand protein function, and domain family-based analysis has had a profound impact on the study of individual proteins. Protein domain discovery has been progressing steadily over the past 30 years. What are the realistically achievable goals of sequence-based domain analysis, and how far off are they for the sequences encoded in eukaryotic genomes? Here we address some of the issues involved in better coverage of sequence-based domain annotation, and the integration of these results within the wider context of genomes, structures and function.
Keywords:Evolution, Genome Analysis, Protein Domains, Sequence Analysis
Source:FEBS Letters
Publisher:Elsevier (The Netherlands)
Page Range:129-134
Date:1 January 2002
PubMed:View item in PubMed

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