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MHC molecules as peptide receptors

Item Type:Review
Title:MHC molecules as peptide receptors
Creators Name:Rammensee, H.G. and Falk, K. and Roetzschke, O.
Abstract:The central unit for regulation of the specific immune system is a trimolecular complex made up of the T cell antigen receptor, the MHC molecule, and the MHC ligand. The third component is a peptide derived as a degradation product from a protein. During recent years there has been some progress in understanding the interaction between MHC molecules and their peptide ligands: MHC molecules are peptide receptors of peculiar specificity, being able to accommodate millions of different peptides provided they share some common features.
Keywords:Alleles, Amino Acid Sequence, Antigen-Presenting Cells, Binding Sites, Biological Transport, Epitopes, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Biological Models, Molecular Sequence Data, Peptide Fragments, Protein Binding, beta 2-Microglobulin, Animals
Source:Current Opinion in Immunology
Page Range:35-44
Date:1 February 1993
Official Publication:https://doi.org/10.1016/0952-7915(93)90078-7
PubMed:View item in PubMed

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