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Peptide motifs of HLA-B51, -B52 and -B78 molecules, and implications for Behcet's disease

Item Type:Article
Title:Peptide motifs of HLA-B51, -B52 and -B78 molecules, and implications for Behcet's disease
Creators Name:Falk, K. and Roetzschke, O. and Takiguchi, M. and Gnau, V. and Stevanovic, S. and Jung, G. and Rammensee, H.G.
Abstract:Here we report peptide motifs of five HLA-B molecules, B*5101, B*5102, B*5103 B*5201 and B*7801. Motifs were obtained by pool sequencing of natural ligands eluted from the respective molecules expressed in C1R cells upon transfection. A number of individual ligands that could be sequenced confirmed the motifs. All five HLA-B molecules belong to the HLA-B5, B35-cross-reactive group and are closely related as indicated by similar sequences. B51 and B52 are associated with Bw4, whereas B78 is associated with Bw6. One of the HLA-B molecules investigated here, HLA-B*5101, is associated with Behçet's disease, a multisystemic inflammatory disease affecting various organs. This disease is especially frequent among the Japanese population. The subtle differences between the peptide motifs of B*5101 as compared with the motifs of the four other closely related but not disease-associated molecules could shed light on the nature of the HLA-association of Behçet's disease.
Keywords:Disease Association, HLA-B51, HLA-B52, HLA-B78, HLA-B*5101, HLA-B*5102, HLA-B*5103, HLA-B*5201, HLA-B*7801, HLA class I, HLA Ligands, Pool Sequencing
Source:International Immunology
Publisher:Oxford University Press
Page Range:223-228
Date:1 February 1995
Official Publication:https://doi.org/10.1093/intimm/7.2.223
PubMed:View item in PubMed

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