Peptide motifs of HLA-B51, -B52 and -B78 molecules, and implications for Behcet's disease

Item Type:	Article
Title:	Peptide motifs of HLA-B51, -B52 and -B78 molecules, and implications for Behcet's disease
Creators Name:	Falk, K. and Roetzschke, O. and Takiguchi, M. and Gnau, V. and Stevanovic, S. and Jung, G. and Rammensee, H.G.
Abstract:	Here we report peptide motifs of five HLA-B molecules, B5101, B5102, B5103 B5201 and B7801. Motifs were obtained by pool sequencing of natural ligands eluted from the respective molecules expressed in C1R cells upon transfection. A number of individual ligands that could be sequenced confirmed the motifs. All five HLA-B molecules belong to the HLA-B5, B35-cross-reactive group and are closely related as indicated by similar sequences. B51 and B52 are associated with Bw4, whereas B78 is associated with Bw6. One of the HLA-B molecules investigated here, HLA-B5101, is associated with Behçet's disease, a multisystemic inflammatory disease affecting various organs. This disease is especially frequent among the Japanese population. The subtle differences between the peptide motifs of B*5101 as compared with the motifs of the four other closely related but not disease-associated molecules could shed light on the nature of the HLA-association of Behçet's disease.
Keywords:	Disease Association, HLA-B51, HLA-B52, HLA-B78, HLA-B5101, HLA-B5102, HLA-B5103, HLA-B5201, HLA-B*7801, HLA class I, HLA Ligands, Pool Sequencing
Source:	International Immunology
ISSN:	0953-8178
Publisher:	Oxford University Press
Volume:	7
Number:	2
Page Range:	223-228
Date:	1 February 1995
Official Publication:	https://doi.org/10.1093/intimm/7.2.223
PubMed:	View item in PubMed

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