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The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice

Official URL:https://doi.org/10.1016/S0896-6273(01)00547-5
PubMed:View item in PubMed
Creators Name:Price, M.P. and McIlwrath, S.L. and Xie, J.H. and Cheng, C. and Qiao, J. and Tarr, D.E. and Sluka, K.A. and Brennan, T.J. and Lewin, G.R. and Welsh, M.J.
Journal Title:Neuron
Journal Abbreviation:Neuron
Volume:32
Number:6
Page Range:1071-1083
Date:20 December 2001
Keywords:Acids, Animal Behavior, Hot Temperature, Mechanoreceptors, Membrane Potentials, Membrane Proteins, Nerve Endings, Nerve Tissue Proteins, Afferent Neurons, Nociceptors, Pain, Patch-Clamp Techniques, Physical Stimulation, Genetic Recombination, Sodium Channels, Chemical Stimulation, Touch, Animals, Mice
Abstract:Cation channels in the DEG/ENaC family are proposed to detect cutaneous stimuli in mammals. We localized one such channel, DRASIC, in several different specialized sensory nerve endings of skin, suggesting it might participate in mechanosensation and/or acid-evoked nociception. Disrupting the mouse DRASIC gene altered sensory transduction in specific and distinct ways. Loss of DRASIC increased the sensitivity of mechanoreceptors detecting light touch, but it reduced the sensitivity of a mechanoreceptor responding to noxious pinch and decreased the response of acid- and noxious heat-sensitive nociceptors. The data suggest that DRASIC subunits participate in heteromultimeric channel complexes in sensory neurons. Moreover, in different cellular contexts, DRASIC may respond to mechanical stimuli or to low pH to mediate normal touch and pain sensation.
ISSN:0896-6273
Publisher:Cell Press (U.S.A.)
Additional Information:Correction in Neuron,35, 2002, 407
Item Type:Article

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