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Tumor rejection by disturbing tumor stroma cell interactions

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Item Type:Article
Title:Tumor rejection by disturbing tumor stroma cell interactions
Creators Name:Ibe, S. and Qin, Z.H. and Schueler, T. and Preiss, S. and Blankenstein, T.
Abstract:The stroma of solid tumors is a complex network of different cell types. We analyzed stroma cell interactions in two tumor models during cyclophosphamide (Cy)-induced tumor rejection. In growing tumors, tumor infiltrating macrophages (TIMs) produced interleukin (IL)-10. Beginning 6 h after Cy-treatment T cells in the tumor were inactivated and TIMs switched to interferon (IFN)-gamma production. Both, IL-10 production before and IFN-gamma production after Cy-treatment by TIMs required T cells. With the same kinetics as TIMs started to produce IFN-gamma the tumor vasculature was destroyed which required IFN-gamma receptor expression on host but not tumor cells. These events preceded hemorrhagic necrosis and residual tumor cell elimination by T cells. Together, T cells regulate the function of TIMs and tumor rejection can be induced by disturbing the stroma network.
Keywords:Tumor Stroma, Tumor Infiltrating Macrophages, IFN-gamma, Antiangiogenesis, Cyclophosphamid, Animals, Mice
Source:Journal of Experimental Medicine
Publisher:Rockefeller University Press
Page Range:1549-1559
Date:3 December 2001
Official Publication:https://doi.org/10.1084/jem.194.11.1549
PubMed:View item in PubMed

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