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| Item Type: | Article |
|---|---|
| Title: | Tumor rejection by disturbing tumor stroma cell interactions |
| Creators Name: | Ibe, S. and Qin, Z.H. and Schueler, T. and Preiss, S. and Blankenstein, T. |
| Abstract: | The stroma of solid tumors is a complex network of different cell types. We analyzed stroma cell interactions in two tumor models during cyclophosphamide (Cy)-induced tumor rejection. In growing tumors, tumor infiltrating macrophages (TIMs) produced interleukin (IL)-10. Beginning 6 h after Cy-treatment T cells in the tumor were inactivated and TIMs switched to interferon (IFN)-gamma production. Both, IL-10 production before and IFN-gamma production after Cy-treatment by TIMs required T cells. With the same kinetics as TIMs started to produce IFN-gamma the tumor vasculature was destroyed which required IFN-gamma receptor expression on host but not tumor cells. These events preceded hemorrhagic necrosis and residual tumor cell elimination by T cells. Together, T cells regulate the function of TIMs and tumor rejection can be induced by disturbing the stroma network. |
| Keywords: | Tumor Stroma, Tumor Infiltrating Macrophages, IFN-gamma, Antiangiogenesis, Cyclophosphamid, Animals, Mice |
| Source: | Journal of Experimental Medicine |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Volume: | 194 |
| Number: | 11 |
| Page Range: | 1549-1559 |
| Date: | 3 December 2001 |
| Official Publication: | https://doi.org/10.1084/jem.194.11.1549 |
| PubMed: | View item in PubMed |
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