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Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices

Item Type:Article
Title:Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices
Creators Name:Schmidt-Ullrich, R. and Aebischer, T. and Huelsken, J. and Birchmeier, W. and Klemm, U. and Scheidereit, C.
Abstract:NF-κB/Rel transcription factors and IκB kinases (IKK) are essential for inflammation and immune responses, but also for bone-morphogenesis, skin proliferation and differentiation. Determining their other functions has previously been impossible, owing to embryonic lethality of NF-κB/Rel or IKK-deficient animals. Using a gene targeting approach we have ubiquitously expressed an NF-κB super-repressor to investigate NF-κB functions in the adult. Mice with suppressed NF-κB revealed defective early morphogenesis of hair follicles, exocrine glands and teeth, identical to Eda (tabby) and Edar (downless) mutant mice. These affected epithelial appendices normally display high NF-κB activity, suppression of which resulted in increased apoptosis, indicating that NF-κB acts as a survival factor downstream of the tumor necrosis factor receptor family member EDAR. Furthermore, NF-κB is required for peripheral lymph node formation and macrophage function.
Keywords:Cre-loxP, Drug Targeting, Hypohidrotic Ectodermal Dysplasia (HED), Immunity, Mouse, Skin Disease, Animals, Mice
Publisher:Company of Biologists
Page Range:3843-3853
Date:1 January 2001
Official Publication:http://dev.biologists.org/cgi/content/abstract/128/19/3843
PubMed:View item in PubMed

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