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4-Hydroxynonenal impairs the permeability of an in vitro rat blood-brain barrier

Item Type:Article
Title:4-Hydroxynonenal impairs the permeability of an in vitro rat blood-brain barrier
Creators Name:Mertsch, K. and Blasig, I. and Grune, T.
Abstract:The function of the blood-brain barrier (BBB) can be impaired by free radicals. Since free radicals have only a limited diffusion capacity, we tested the possibility whether one of the major secondary lipid peroxidation product - 4-hydroxynonenal, is able to influence the permeability of the BBB. Therefore, we established an in vitro BBB model and tested its capacity to degrade 4-hydroxynonenal. Although, endothelial cells and astrocytes, posses the ability to degrade 4-hydroxynonenal the aldehyde is able to increase the permeability of the BBB. Since aldehydic lipid peroxidation products are metabolized via conjugation with glutathione we proofed that a decrease in glutathione is also able to increase the permeability of the BBB. We concluded that 4-hydroxynonenal is able to impair the BBB function via the decrease of reduced glutathione.
Keywords:4-Hydroxynonenal, Astrocytes, Blood-Brain Barrier, Endothelial Cells, Glutathione, Oxidative Stress, Animals, Rats
Source:Neuroscience Letters
ISSN:0304-3940
Publisher:Elsevier (The Netherlands)
Volume:314
Number:3
Page Range:135-138
Date:1 January 2001
Official Publication:https://doi.org/10.1016/S0304-3940(01)02299-6
PubMed:View item in PubMed

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