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New aspects of Wnt signaling pathways in higher vertebrates

Item Type:Review
Title:New aspects of Wnt signaling pathways in higher vertebrates
Creators Name:Huelsken, J. and Birchmeier, W.
Abstract:The development of tissues and organs in embryos is controlled by an interplay of several signaling pathways that cross-talk to provide positional information and induce cell fate specification. One of the major signaling systems is the Wnt pathway which was recently shown to split into several intracellular branches which regulate multiple cellular functions. In the present review, we discuss novel members and their role in the diversification of the Wnt pathway. Many of these components were studied in model organisms such as C.elegans, Drosophila and Xenopus. Here we focus on recent studies of mutant phenotypes in Mouse and Zebrafish which implicate members of the Wnt pathway in processes such as axis and mesoderm formation, initiation of organ development and stem cell differentiation.
Keywords:Body Patterning, Cell Differentiation, Cytoskeletal Proteins, Embryonic and Fetal Development, Mesoderm, Proto-Oncogene Proteins, Signal Transduction, Stem Cells, Trans-Activators, Vertebrates, Wnt Proteins, Zebrafish Proteins, beta Catenin, Animals
Source:Current Opinion in Genetics & Development
ISSN:0959-437X
Publisher:Current Biology Ltd (U.S.A.)
Volume:11
Number:5
Page Range:547-553
Date:1 October 2001
Official Publication:https://doi.org/10.1016/S0959-437X(00)00231-8
PubMed:View item in PubMed

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