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New aspects of Wnt signaling pathways in higher vertebrates

Official URL:https://doi.org/10.1016/S0959-437X(00)00231-8
PubMed:View item in PubMed
Creators Name:Huelsken, J. and Birchmeier, W.
Journal Title:Current Opinion in Genetics & Development
Journal Abbreviation:Curr Opin Dev
Page Range:547-553
Date:1 October 2001
Keywords:Body Patterning, Cell Differentiation, Cytoskeletal Proteins, Embryonic and Fetal Development, Mesoderm, Proto-Oncogene Proteins, Signal Transduction, Stem Cells, Trans-Activators, Vertebrates, Wnt Proteins, Zebrafish Proteins, beta Catenin, Animals
Abstract:The development of tissues and organs in embryos is controlled by an interplay of several signaling pathways that cross-talk to provide positional information and induce cell fate specification. One of the major signaling systems is the Wnt pathway which was recently shown to split into several intracellular branches which regulate multiple cellular functions. In the present review, we discuss novel members and their role in the diversification of the Wnt pathway. Many of these components were studied in model organisms such as C.elegans, Drosophila and Xenopus. Here we focus on recent studies of mutant phenotypes in Mouse and Zebrafish which implicate members of the Wnt pathway in processes such as axis and mesoderm formation, initiation of organ development and stem cell differentiation.
Publisher:Current Biology Ltd (U.S.A.)
Item Type:Review

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