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High-throughput three-dimensional protein structure determination

Item Type:Review
Title:High-throughput three-dimensional protein structure determination
Creators Name:Heinemann, U. and Illing, G. and Oschkinat, H.
Abstract:In the wake of finished genomic sequencing projects, high-throughput analysis techniques are being developed in various fields of functional genomics. Of special interest in this regard is the three-dimensional structure analysis of proteins by X-ray crystallography and NMR spectroscopy, which has been characterized by distinctly low-throughput in the past. A number of recent advances in instrumentation and software are promising to radically change this situation, leaving the production of suitable protein samples as the sole rate-limiting step in structural analyses.
Keywords:Biomolecular Nuclear Magnetic Resonance, Green Fluorescent Proteins, Luminescent Proteins, Protein Folding, Tertiary Protein Structure, X-Ray Crystallography, X-Ray Diffraction
Source:Current Opinion in Biotechnology
Publisher:Current Biology
Page Range:348-354
Date:1 January 2001
Official Publication:https://doi.org/10.1016/S0958-1669(00)00226-3
PubMed:View item in PubMed

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