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Sox9 induces testis development in XX transgenic mice

Item Type:Article
Title:Sox9 induces testis development in XX transgenic mice
Creators Name:Vidal, V.P.I. and Chaboissier, M.C. and de Rooij, D.G. and Schedl, A.
Abstract:Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.
Keywords:High Mobility Group Proteins, Phenotype, SOX9 Transcription Factor, Gonadal Sex Reversal, Transcription Factors, X Chromosome, Animals, Mice
Source:Nature Genetics
ISSN:1061-4036
Publisher:Nature Publishing Group (U.S.A.)
Volume:28
Number:3
Page Range:216-217
Date:1 July 2001
Official Publication:https://doi.org/10.1038/90046
PubMed:View item in PubMed

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