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Sox9 induces testis development in XX transgenic mice

Official URL:https://doi.org/10.1038/90046
PubMed:View item in PubMed
Creators Name:Vidal, V.P.I. and Chaboissier, M.C. and de Rooij, D.G. and Schedl, A.
Journal Title:Nature Genetics
Journal Abbreviation:Nat Genet
Volume:28
Number:3
Page Range:216-217
Date:1 July 2001
Keywords:High Mobility Group Proteins, Phenotype, SOX9 Transcription Factor, Gonadal Sex Reversal, Transcription Factors, X Chromosome, Animals, Mice
Abstract:Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.
ISSN:1061-4036
Publisher:Nature Publishing Group (U.S.A.)
Item Type:Article

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