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Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells

Official URL:https://doi.org/10.1038/87740
PubMed:View item in PubMed
Creators Name:Ugolini, S. and Arpin, C. and Anfossi, N. and Walzer, T. and Cambiaggi, A. and Foerster, R. and Lipp, M. and Toes, R.E.M. and Melief, C.J. and Marvel, J. and Vivier, E.
Journal Title:Nature Immunology
Journal Abbreviation:Nat Immunol
Page Range:430-435
Date:1 January 2001
Keywords:CD8-Positive T-Lymphocytes, Cell Death, HLA-C Antigens, Immunologic Memory, Natural Killer Cells, Mice, Transgenic Mice, Phenotype, Immunologic Receptors, Spleen, T-Lymphocyte Subsets, Vaccination
Abstract:Inhibitory natural killer receptors (NKRs) such as killer cell immunoglobulin-like receptors (KIRs) in humans and Ly49 molecules in mice are expressed on NK cells and recognize multiple major histocompatibility (MHC) class I proteins. In humans and mice, a subset of CD8 + T cells also expresses NKRs and harbors a memory phenotype. Using mice that are transgenic for K1R2DL3 and its cognate HLA-Cw3 ligand, we show that engagement of inhibitory NKRs selectively drives the in vivo accumulation of a subset of memory-phenotype CD8 + T cells that express the β chain of the interleukin 2 receptor. In vitro, recognition of MHC class I molecules by inhibitory NKRs on T cells down-regulated activation-induced cell death. These results unveil an MHC class I-dependent pathway that promotes the survival of a subset of memory-phenotype CD8 + T cells and also reveal an unexpected biological function for inhibitory NKRs on T cells.
Publisher:Nature Publishing Group (U.S.A.)
Item Type:Article

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