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Chromatin remodeling in development and differentiation

PubMed:View item in PubMed
Creators Name:Mueller, C. and Leutz, A.
Journal Title:Current Opinion in Genetics & Development
Journal Abbreviation:Curr Opin Dev
Page Range:167-174
Date:1 January 2001
Keywords:Cell Differentiation, Cell Lineage, Chromatin, Developmental Gene Expression Regulation, Gene Expression Regulation, Hematopoiesis, Leukemia, Animals
Abstract:During development and differentiation, early inductive processes that influence cell fate at a later stage leave marks at distinct gene loci that are maintained through several rounds of mitosis. The structure of chromatin is part of this epigenetic memory that restricts or permits differential expression of genes in descendant cells. Establishing a cell-type-specific chromatin pattern thus predestines future cell differentiation and deters cell-lineage infidelity, as it often occurs during neoplastic transformation. As such, understanding the dynamics and mechanisms underlying chromatin remodeling has been a major focus of recent molecular genetic research that holds great promise for biomedical discoveries.
Publisher:Current Biology Ltd (U.S.A.)
Item Type:Review

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