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Chromatin remodeling in development and differentiation

Item Type:Review
Title:Chromatin remodeling in development and differentiation
Creators Name:Mueller, C. and Leutz, A.
Abstract:During development and differentiation, early inductive processes that influence cell fate at a later stage leave marks at distinct gene loci that are maintained through several rounds of mitosis. The structure of chromatin is part of this epigenetic memory that restricts or permits differential expression of genes in descendant cells. Establishing a cell-type-specific chromatin pattern thus predestines future cell differentiation and deters cell-lineage infidelity, as it often occurs during neoplastic transformation. As such, understanding the dynamics and mechanisms underlying chromatin remodeling has been a major focus of recent molecular genetic research that holds great promise for biomedical discoveries.
Keywords:Cell Differentiation, Cell Lineage, Chromatin, Developmental Gene Expression Regulation, Gene Expression Regulation, Hematopoiesis, Leukemia, Animals
Source:Current Opinion in Genetics & Development
ISSN:0959-437X
Publisher:Current Biology Ltd (U.S.A.)
Volume:11
Number:2
Page Range:167-174
Date:1 January 2001
PubMed:View item in PubMed

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