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Identification of a recurrent BRCA1 mutation in German breast-cancer and/or ovarian-cancer families

Item Type:Article
Title:Identification of a recurrent BRCA1 mutation in German breast-cancer and/or ovarian-cancer families
Creators Name:Hofmann, W. and Jandrig, B. and Classen, E. and Nestle-Kraemling, C. and Chang-Claude, J. and Scherneck, S.
Abstract:Specific BRCA1 mutations have been reported to be common within particular populations. We have investigated German breast- and/or ovarian-cancer families and detected a recurrent carboxy-terminal BRCA1 mutation, 5622C > T, using PCR-based restriction assay and haplotype analysis. Unrelated families carrying this BRCA1 mutation shared two different disease-associated haplotypes, indicating two independent mutation events.
Keywords:BRCA1, Hereditary Breast Cancer, Mutation, Ovarian Cancer
Source:Journal of Cancer Research and Clinical Oncology
ISSN:0171-5216
Publisher:Springer (Germany)
Volume:127
Number:3
Page Range:200-202
Date:1 January 2001
PubMed:View item in PubMed

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