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Initial sequencing and analysis of the human genome

Item Type:Review
Title:Initial sequencing and analysis of the human genome
Creators Name:Lander, E.S. and Linton, L.M. and Birren, B. and Nusbaum, C. and Zody, M.C. and Baldwin, J. and Devon, K. and Dewar, K. and Doyle, M. and FitzHugh, W. and Funke, R. and Gage, D. and Harris, K. and Heaford, A. and Howland, J. and Kann, L. and Lehoczky, J. and LeVine, R. and McEwan, P. and McKernan, K. and Meldrim, J. and Mesirov, J.P. and Miranda, C. and Morris, W. and Naylor, J. and Raymond, C. and Rosetti, M. and Santos, R. and Sheridan, A. and Sougnez, C. and Stange-Thomann, N. and Stojanovic, N. and Subramanian, A. and Wyman, D. and Rogers, J. and Sulston, J. and Ainscough, R. and Beck, S. and Bentley, D. and Burton, J. and Clee, C. and Carter, N. and Coulson, A. and Deadman, R. and Deloukas, P. and Dunham, A. and Dunham, I. and Durbin, R. and French, L. and Grafham, D. and Gregory, S. and Hubbard, T. and Humphray, S. and Hunt, A. and Jones, M. and Lloyd, C. and McMurray, A. and Matthews, L. and Mercer, S. and Milne, S. and Mullikin, J.C. and Mungall, A. and Plumb, R. and Ross, M. and Shownkeen, R. and Sims, S. and Waterston, R.H. and Wilson, R.K. and Hillier, L.W. and McPherson, J.D. and Marra, M.A. and Mardis, E.R. and Fulton, L.A. and Chinwalla, A.T. and Pepin, K.H. and Gish, W.R. and Chissoe, S.L. and Wendl, M.C. and Delehaunty, K.D. and Miner, T.L. and Delehaunty, A. and Kramer, J.B. and Cook, L.L. and Fulton, R.S. and Johnson, D.L. and Minx, P.J. and Clifton, S.W. and Hawkins, T. and Branscomb, E. and Predki, P. and Richardson, P. and Wenning, S. and Slezak, T. and Doggett, N. and Cheng, J.F. and Olsen, A. and Lucas, S. and Elkin, C. and Uberbacher, E. and Frazier, M. and Gibbs, R.A. and Muzny, D.M. and Scherer, S.E. and Bouck, J.B. and Sodergren, E.J. and Worley, K.C. and Rives, C.M. and Gorrell, J.H. and Metzker, M.L. and Naylor, S.L. and Kucherlapati, R.S. and Nelson, D.L. and Weinstock, G.M. and Sakaki, Y. and Fujiyama, A. and Hattori, M. and Yada, T. and Toyoda, A. and Itoh, T. and Kawagoe, C. and Watanabe, H. and Totoki, Y. and Taylor, T. and Weissenbach, J. and Heilig, R. and Saurin, W. and Artiguenave, F. and Brottier, P. and Bruls, T. and Pelletier, E. and Robert, C. and Wincker, P. and Rosenthal, A. and Platzer, M. and Nyakatura, G. and Taudien, S. and Rump, A. and Yang, H.M. and Yu, J. and Wang, J. and Huang, G.Y. and Gu, J. and Hood, L. and Rowen, L. and Madan, A. and Qin, S.Z. and Davis, R.W. and Federspiel, N.A. and Abola, A.P. and Proctor, M.J. and Myers, R.M. and Schmutz, J. and Dickson, M. and Grimwood, J. and Cox, D.R. and Olson, M.V.
Abstract:The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.
Keywords:Chromosome Mapping, Conserved Sequence, CpG Islands, DNA Transposable Elements, Factual Databases, Drug Industry, Molecular Evolution, Forecasting, GC Rich Sequence, Gene Duplication, Genes, Inborn Genetic Diseases, Medical Genetics, Human Genome, Human Genome Project, Humans, Mutation, Private Sector, Proteins, Proteome, Public Sector, RNA, Nucleic Acid Repetitive Sequences, DNA Sequence Analysis, Species Specificity, Animals
Source:Nature
ISSN:0028-0836
Publisher:Nature Publishing Group (U.K.)
Volume:409
Number:6822
Page Range:860-921
Date:15 February 2001
Official Publication:https://doi.org/10.1038/35057062
PubMed:View item in PubMed

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