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The impact of c-met/scatter factor receptor on dendritic cell migration

Item Type:Article
Title:The impact of c-met/scatter factor receptor on dendritic cell migration
Creators Name:Kurz, S.M. and Diebold, S.S. and Hieronymus, T. and Gust, T.C. and Bartunek, P. and Sachs, M. and Birchmeier, W. and Zenke, M.
Abstract:Dendritic cells (DC) are professional antigen-presenting cells that possess both migratory properties and potent T cell stimulatory activity, and that allow the uptake of antigenic material in peripheral tissues and its subsequent presentation in the T cell areas of lymphoid organs. Thus motility represents a central property that is required for DC function. Here we report on the expression of the receptor tyrosine kinase c-met in DC. c-Met is the high affinity receptor for scatter factor (SF)/hepatocyte growth factor, and ligand-activated c-met exhibits mitogenic, morphogenic and motogenic activity in vivo and in vitro. c-Met is signaling competent in DC since it is effectively tyrosine phosphorylated in response to SF ligand. It is demonstrated here that ligand-activated c-met regulates DC adhesion to the extracellular matrix component laminin but leaves antigen presenting function unaffected. Importantly, in ear sheet explant experiments activation of c-met by ligand induces emigration of cutaneous DC (Langerhans cell, LC) from skin, but SF is not a chemoattractant factor for DC. Our results suggest an important role of the c-met/SF system in DC/LC migration.
Keywords:Antigen Presentation, c-Met, Dendritic Cell, Migration, Scatter Factor, Animals, Mice
Source:European Journal of Immunology
ISSN:0014-2980
Publisher:Wiley (U.S.A.)
Volume:32
Number:7
Page Range:1832-1838
Date:1 January 2002
Official Publication:https://doi.org/10.1002/1521-4141(200207)32:7<1832::AID-IMMU1832>3.0.CO;2-2
PubMed:View item in PubMed

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