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Suicide gene therapy for pediatric tumors

Item Type:Review
Title:Suicide gene therapy for pediatric tumors
Creators Name:Beltinger, C. and Uckert, W. and Debatin, K.M.
Abstract:Tumor gene therapy is potentially very specific and efficacious. Suicide genes are promising tools in the arsenal of tumor gene therapy. However, problems of tumor targeting, low in vivo efficacy of nucleic acid transfer, and recent reports of adverse effects hinder the translation of this approach into clinical practice. Therefore vector design, tumor targeting, mechanisms of cell kill and killing of untransfected tumor cells must be improved. Once these problems are solved in vitro and in animal models, gene therapy holds great promise for pediatric oncology given the abundance of specific targets in pediatric tumors. This review describes the current state of preclinical research in tumor suicide gene therapy, provides an outline of pediatric suicide gene therapy protocols, and identifies potential targets in pediatric malignancies.
Keywords:Cancer, Children, Gene Therapy, Suicide Genes, Vectors
Source:Journal of Molecular Medicine
Page Range:598-612
Date:1 January 2001
Official Publication:https://doi.org/10.1007/s001090000175
PubMed:View item in PubMed

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