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CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function

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Item Type:Article
Title:CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
Creators Name:Schaerli, P. and Willimann, K. and Lang, A.B. and Lipp, M. and Loetscher, P. and Moser, B.
Abstract:Leukocyte traffic through secondary lymphoid tissues is finely tuned by chemokines. We have studied the functional properties of a human T cell subset marked by the expression of CXC chemokine receptor 5 (CXCR5). Memory but not naive T cells from tonsils are CXCR5(+) and migrate in response to the B cell-attracting chemokine 1 (BCA-1), which is selectively expressed by reticular cells and blood vessels within B cell follicles. Tonsillar CXCR5(+) T cells do not respond to other chemokines present in secondary lymphoid tissues, including secondary lymphoid tissue chemokine (SLC), EBV-induced molecule 1 ligand chemokine (ELC), and stromal cell-derived factor 1 (SDF-1). The involvement of tonsillar CXCR5(+) T cells in humoral immune responses is suggested by their localization in the mantle and light zone germinal centers of B cell follicles and by the concomitant expression of activation and costimulatory markers, including CD69, HLA-DR, and inducible costimulator (ICOS). Peripheral blood CXCR5(+) T cells also belong to the CD4(+) memory T cell subset but, in contrast to tonsillar cells, are in a resting state and migrate weakly to chemokines. CXCR5(+) T cells are very inefficient in the production of cytokines but potently induce antibody production during coculture with B cells. These properties portray CXCR5(+) T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (T(FH)).
Keywords:Chemokines, CXC Chemokine Receptor 5, Lymphocytes, B Cell Follicle, Antibodies , Animals
Source:Journal of Experimental Medicine
Publisher:Rockefeller University Press
Page Range:1553-1562
Date:4 December 2000
Official Publication:http://www.jem.org/cgi/content/abstract/192/11/1553
PubMed:View item in PubMed

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