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| Item Type: | Article |
|---|---|
| Title: | CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function |
| Creators Name: | Schaerli, P. and Willimann, K. and Lang, A.B. and Lipp, M. and Loetscher, P. and Moser, B. |
| Abstract: | Leukocyte traffic through secondary lymphoid tissues is finely tuned by chemokines. We have studied the functional properties of a human T cell subset marked by the expression of CXC chemokine receptor 5 (CXCR5). Memory but not naive T cells from tonsils are CXCR5(+) and migrate in response to the B cell-attracting chemokine 1 (BCA-1), which is selectively expressed by reticular cells and blood vessels within B cell follicles. Tonsillar CXCR5(+) T cells do not respond to other chemokines present in secondary lymphoid tissues, including secondary lymphoid tissue chemokine (SLC), EBV-induced molecule 1 ligand chemokine (ELC), and stromal cell-derived factor 1 (SDF-1). The involvement of tonsillar CXCR5(+) T cells in humoral immune responses is suggested by their localization in the mantle and light zone germinal centers of B cell follicles and by the concomitant expression of activation and costimulatory markers, including CD69, HLA-DR, and inducible costimulator (ICOS). Peripheral blood CXCR5(+) T cells also belong to the CD4(+) memory T cell subset but, in contrast to tonsillar cells, are in a resting state and migrate weakly to chemokines. CXCR5(+) T cells are very inefficient in the production of cytokines but potently induce antibody production during coculture with B cells. These properties portray CXCR5(+) T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (T(FH)). |
| Keywords: | Chemokines, CXC Chemokine Receptor 5, Lymphocytes, B Cell Follicle, Antibodies , Animals |
| Source: | Journal of Experimental Medicine |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Volume: | 192 |
| Number: | 11 |
| Page Range: | 1553-1562 |
| Date: | 4 December 2000 |
| Official Publication: | http://www.jem.org/cgi/content/abstract/192/11/1553 |
| PubMed: | View item in PubMed |
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