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| Item Type: | Article |
|---|---|
| Title: | Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production |
| Creators Name: | Breitfeld, D. and Ohl, L. and Kremmer, E. and Ellwart, J. and Sallusto, F. and Lipp, M. and Foerster, R. |
| Abstract: | Chemokines and their receptors have been identified as major regulators controlling the functional organization of secondary lymphoid organs. Here we show that expression of CXC chemokine receptor 5 (CXCR5), a chemokine receptor required for B cell homing to B cell follicles, defines a novel subpopulation of B helper T cells localizing to follicles. In peripheral blood these cells coexpress CD45RO and the T cell homing CC chemokine receptor 7 (CCR7). In secondary lymphoid organs, CD4(+)CXCR5(+) cells lose expression of CCR7, which allows them to localize to B cell follicles and germinal centers where they express high levels of CD40 ligand (CD40L), a costimulatory molecule required for B cell activation and inducible costimulator (ICOS), a recently identified costimulatory molecule of the CD28 family. Thus, when compared with CD4(+)CD45RO(+)CXCR5(-) cells, CD4(+)CD45RO(+)CXCR5(+) tonsillar T cells efficiently support the production of immunoglobulin (Ig)A and IgG. In contrast, analysis of the memory response revealed that long-lasting memory cells are found within the CD4(+)CD45RO(+)CXCR5(-) population, suggesting that CXCR5(+)CD4 cells represent recently activated effector cells. Based on the characteristic localization within secondary lymphoid organs, we suggest to term these cells "follicular B helper T cells" (T(FH)). |
| Keywords: | CXC Chemokine Receptor 5, CC Chemokine Receptor 7, T Cell Homing, Germinal Centers, T Helper Cells |
| Source: | Journal of Experimental Medicine |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Volume: | 192 |
| Number: | 11 |
| Page Range: | 1545-1551 |
| Date: | 4 December 2000 |
| Official Publication: | http://www.jem.org/cgi/content/abstract/192/11/1545 |
| PubMed: | View item in PubMed |
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