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Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production

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Official URL:http://www.jem.org/cgi/content/abstract/192/11/1545
PubMed:View item in PubMed
Creators Name:Breitfeld, D. and Ohl, L. and Kremmer, E. and Ellwart, J. and Sallusto, F. and Lipp, M. and Foerster, R.
Journal Title:Journal of Experimental Medicine
Journal Abbreviation:J Exp Med
Volume:192
Number:11
Page Range:1545-1551
Date:4 December 2000
Keywords:CXC Chemokine Receptor 5, CC Chemokine Receptor 7, T Cell Homing, Germinal Centers, T Helper Cells
Abstract:Chemokines and their receptors have been identified as major regulators controlling the functional organization of secondary lymphoid organs. Here we show that expression of CXC chemokine receptor 5 (CXCR5), a chemokine receptor required for B cell homing to B cell follicles, defines a novel subpopulation of B helper T cells localizing to follicles. In peripheral blood these cells coexpress CD45RO and the T cell homing CC chemokine receptor 7 (CCR7). In secondary lymphoid organs, CD4(+)CXCR5(+) cells lose expression of CCR7, which allows them to localize to B cell follicles and germinal centers where they express high levels of CD40 ligand (CD40L), a costimulatory molecule required for B cell activation and inducible costimulator (ICOS), a recently identified costimulatory molecule of the CD28 family. Thus, when compared with CD4(+)CD45RO(+)CXCR5(-) cells, CD4(+)CD45RO(+)CXCR5(+) tonsillar T cells efficiently support the production of immunoglobulin (Ig)A and IgG. In contrast, analysis of the memory response revealed that long-lasting memory cells are found within the CD4(+)CD45RO(+)CXCR5(-) population, suggesting that CXCR5(+)CD4 cells represent recently activated effector cells. Based on the characteristic localization within secondary lymphoid organs, we suggest to term these cells "follicular B helper T cells" (T(FH)).
ISSN:0022-1007
Publisher:Rockefeller University Press (U.S.A.)
Item Type:Article

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