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Genes that control the development of migrating muscle precursor cells

PubMed:View item in PubMed
Creators Name:Birchmeier, C. and Brohmann, H.
Journal Title:Current Opinion in Cell Biology
Journal Abbreviation:Curr Opin Cell Biol
Page Range:725-730
Date:1 December 2000
Keywords:Avian Proteins, Body Patterning, Caenorhabditis Elegans, Cell Lineage, Cell Movement, Chick Embryo, Developmental Gene Expression Regulation, DNA-Binding Proteins, Extremities, Hepatocyte Growth Factor, Muscle Proteins, Paired Box Transcription Factors, Proto-Oncogene Proteins c-met, Skeletal Muscle, Stem Cells, Transcription Factors, Animals, Mice
Abstract:Skeletal muscles in vertebrates, despite their functional and biochemical similarities, are generated via diverse developmental mechanisms. A major subclass of hypaxial muscle groups is derived from long-range migrating progenitor cells that delaminate from the dermomyotome. The development of this lineage is controlled by Pax3, the c-Met tyrosine kinase receptor, its ligand SF/HGF (scatter factor/hepatocyte growth factor) and the homeobox factor Lbx1. These molecules are essential for establishment of the precursor pool, delamination, migration and target finding. Progress has been made in understanding patterning of the muscles, which requires a precise control of proliferation and differentiation of myogenic precursor cells.
Publisher:Current Biology Ltd (U.K.)
Item Type:Article

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