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Deletion of the gene encoding H-FABP/MDGI has no overt effects in the mammary gland

Item Type:Article
Title:Deletion of the gene encoding H-FABP/MDGI has no overt effects in the mammary gland
Creators Name:Clark, A.J. and Neil, C. and Gusterson, B. and McWhir, J. and Binas, B.
Abstract:Heart fatty acid binding protein (H-FABP) is expressed abundantly in the mammary gland. A number of in vitro studies have shown that H-FABP is functionally indistinguishable from a factor isolated from this organ, termed mammary derived growth inhibitor (MDGI), which specifically inhibits the proliferation of mammary tissue. We have previously shown that over-expression of H-FABP/MDGI in the mammary gland of transgenic mice has no discernable effects on cell proliferation or differentiation. In this report we describe knockout mouse in which the H-FABP/MDGI gene has been specifically disrupted. The mice exhibit no overt phenotype in the mammary gland, and we conclude that this gene does not play a specific role in regulating the normal development or function of this tissue.
Keywords:Differentiation, Knockout, Proliferation, Animals, Mice
Source:Transgenic Research
ISSN:0962-8819
Publisher:Kluwer Academic Publ (The Netherlands)
Volume:9
Number:6
Page Range:439-444
Date:1 December 2000
Official Publication:https://doi.org/10.1023/A:1026552629493
PubMed:View item in PubMed

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