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Calculating as many fluxes as possible in underdetermined metabolic networks

Item Type:Article
Title:Calculating as many fluxes as possible in underdetermined metabolic networks
Creators Name:Klamt, S. and Schuster, S.
Abstract:A frequently occurring problem in Metabolic Flux Analysis is that the linear equation systems are underdetermined. A procedure for determining which reaction velocities can be calculated in underdetermined metabolic systems from measured rates and computing these velocities is given. The method is based on the null-space matrix to the stoichiometry matrix corresponding to the reactions with unknown velocities. Moreover, an elementary representation of the null-space is presented. This representation enables one to find those sets of measurable velocities that allow calculation of a certain non-measurable rate. The approach is illustrated by an example from monosaccharide metabolism.
Keywords:Biological Models, Biological Transport, Energy Metabolism, Enzymes, Mathematics, Software
Source:Molecular Biology Reports
Publisher:Kluwer Academic Publishers
Page Range:243-248
Date:1 January 2002
Official Publication:https://doi.org/10.1023/A:1020394300385
PubMed:View item in PubMed

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