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Gene context conservation of a higher order than operons

PubMed:View item in PubMed
Creators Name:Lathe, W.C. and Snel, B. and Bork, P.
Journal Title:Trends in Biochemical Sciences
Journal Abbreviation:Trends Biochem Sci
Page Range:474-479
Date:1 October 2000
Keywords:Base Sequence, Conserved Sequence, Molecular Evolution, Gene Order, Operon, Phylogeny, Ribosomal Proteins, Genetic Translation
Abstract:Operons, co-transcribed and co-regulated contiguous sets of genes, are poorly conserved over short periods of evolutionary time. The gene order, gene content and regulatory mechanisms of operons can be very different, even in closely related species. Here, we present several lines of evidence which suggest that, although an operon and its individual genes and regulatory structures are rearranged when comparing the genomes of different species, this rearrangement is a conservative process. Genomic rearrangements invariably maintain individual genes in very specific functional and regulatory contexts. We call this conserved context an uber-operon.
Publisher:Elsevier (The Netherlands)
Item Type:Article

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