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STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene

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Item Type:Article
Title:STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene
Creators Name:Snel, B. and Lehmann, G. and Bork, P. and Huynen, M.A.
Abstract:The repeated occurrence of genes in each other's neighbourhood on genomes has been shown to indicate a functional association between the proteins they encode. Here we introduce STRING (search tool for recurring instances of neighbouring genes), a tool to retrieve and display the genes a query gene repeatedly occurs with in clusters on the genome. The tool performs iterative searches and visualises the results in their genomic context. By finding the genomically associated genes for a query, it delineates a set of potentially functionally associated genes. The usefulness of STRING is illustrated with an example that suggests a functional context for an RNA methylase with unknown specificity.
Keywords:Bacterial Genes, Information Storage and Retrieval, Internet, Mycoplasma, Operon, Software, Substrate Specificity, tRNA Methyltransferases
Source:Nucleic Acids Research
ISSN:0305-1048
Publisher:Oxford University Press (U.K.)
Volume:28
Number:18
Page Range:3442-3444
Date:15 September 2000
Official Publication:http://nar.oxfordjournals.org/cgi/content/abstract/28/18/3442
PubMed:View item in PubMed

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