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| Item Type: | Article |
|---|---|
| Title: | STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene |
| Creators Name: | Snel, B. and Lehmann, G. and Bork, P. and Huynen, M.A. |
| Abstract: | The repeated occurrence of genes in each other's neighbourhood on genomes has been shown to indicate a functional association between the proteins they encode. Here we introduce STRING (search tool for recurring instances of neighbouring genes), a tool to retrieve and display the genes a query gene repeatedly occurs with in clusters on the genome. The tool performs iterative searches and visualises the results in their genomic context. By finding the genomically associated genes for a query, it delineates a set of potentially functionally associated genes. The usefulness of STRING is illustrated with an example that suggests a functional context for an RNA methylase with unknown specificity. |
| Keywords: | Bacterial Genes, Information Storage and Retrieval, Internet, Mycoplasma, Operon, Software, Substrate Specificity, tRNA Methyltransferases |
| Source: | Nucleic Acids Research |
| ISSN: | 0305-1048 |
| Publisher: | Oxford University Press |
| Volume: | 28 |
| Number: | 18 |
| Page Range: | 3442-3444 |
| Date: | 15 September 2000 |
| Official Publication: | http://nar.oxfordjournals.org/cgi/content/abstract/28/18/3442 |
| PubMed: | View item in PubMed |
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