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CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue

Official URL:https://doi.org/10.1016/S1074-7613(00)80201-0
PubMed:View item in PubMed
Creators Name:Cook, D.N. and Prosser, D.M. and Forster, R. and Zhang, J. and Kuklin, N.A. and Abbondanzo, S.J. and Niu, X.D. and Chen, S.C. and Manfra, D.J. and Wiekowski, M.T. and Sullivan, L.M. and Smith, S.R. and Greenberg, H.B. and Narula, S.K. and Lipp, M. and Lira, S.A.
Journal Title:Immunity
Journal Abbreviation:Immunity
Page Range:495-503
Date:1 May 2000
Keywords:CD11 Antigens, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Movement, Dendritic Cells, Mucosal Immunity, CCR6 Receptors, Chemokine Receptors, Animals, Mice
Abstract:Chemokine-directed migration of leukocyte subsets may contribute to the qualitative differences between systemic and mucosal immunity. Here, we demonstrate that in mice lacking the chemokine receptor CCR6, dendritic cells expressing CD11c and CD11b are absent from the subepithelial dome of Peyer's patches. These mice also have an impaired humoral immune response to orally administered antigen and to the enteropathic virus rotavirus. In addition, CCR6(-/-) mice have a 2-fold to 15-fold increase in cells of select T lymphocyte populations within the mucosa, including CD4+ and CD8+ alphabeta-TCR T cells. By contrast, systemic immune responses to subcutaneous antigens in CCR6(-/-) mice are normal. These findings demonstrate that CCR6 is a mucosa-specific regulator of humoral immunity and lymphocyte homeostasis in the intestinal mucosa.
Publisher:Cell Press (U.S.A.)
Item Type:Article

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