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Detection of C-type natriuretic peptide in fetal circulation

Item Type:Article
Title:Detection of C-type natriuretic peptide in fetal circulation
Creators Name:Stepan, H. and Walther, D. and Faber, R. and Walther, T.
Abstract:C-type natriuretic peptide (CNP) belongs to the natriuretic peptide family that plays an important role in the control of blood pressure, renal function and volume homeostasis. In contrast to the atrial natriuretic peptide and brain natriuretic peptide, CNP acts in an autocrine/ paracrine fashion and is considered to be the endothelial component of the natriuretic peptide system. CNP has a high expression and tissue-specific regulation in reproductive organs. Using a radio-immunoassy for CNP-22 we measured for the first time CNP in fetal blood. Samples were taken by cordocentesis in a group of fetuses with rhesus isoimmunisation (10.74 ± 2.81 pg/ml),. fetuses with rhesus isoimmunisation after intravascular transfusion (10.03 ± 4.01 pg/ml) and a group with structural anomalies (12.9 ± 5.67 pg/ml). A group of healthy fetuses was used as controls (11.64 ± 4.32 pg/ml). In contrast to ANP, the fetal CNP-plasma concentrations remain stable in the investigated fetal diseases and after volume load during intravascuIar transfusion. Moreover, fetal CNP-plasma levels are higher than previously measured maternal concentrations in normal pregnancies. Therefore, the fetus expresses CNP independently of the maternal circulation.
Keywords:C-type Natriuretic Peptide, Fetal Circulation, Natriuretic Peptide System, Rhesus Isoimmunisation
Source:Journal of Perinatal Medicine
Publisher:de Gruyter
Page Range:118-121
Date:1 January 2000
Official Publication:https://doi.org/10.1515/JPM.2000.015
PubMed:View item in PubMed

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