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Upregulation of bradykinin B1-receptor expression after myocardial infarction

Item Type:Article
Title:Upregulation of bradykinin B1-receptor expression after myocardial infarction
Creators Name:Tschoepe, C. and Heringer-Walther, S. and Koch, M. and Spillmann, F. and Wendorf, M. and Leitner, E. and Schultheiss, H.P. and Walther, T.
Abstract:To determine the influence of the myocardial infarction (MI) on bradykinin B1-receptor (BIR) regulation, we studied its expression in the left ventricle (LV) after MI. Rats were submitted to a permanent occlusion of the left coronary artery. Six hours, 24 h and 6 days after MI or after sham operation, left ventricular pressure (LVP) and dP/dt(max) were measured. LV-total RNA was extracted and BIR expression was analysed by a RNase-protection assay (each group n = 6). LVP and dP/dt(max) were impaired at all time points after MI. Basal BIR expression was not detectable in controls. Six hours after MI, the BIR expression was upregulated and reached a maximum 24 h after MI (4 fold vs 6 h). Six days post-MI, BIR expression returned to levels found 6 h after MI. These data are the first demonstration for an induced myocardial BIR expression in an in vivo model of MI.
Keywords:B1 Receptor, Bradykinin, Myocardial Infarction, Animals, Rats
Source:British Journal of Pharmacology
ISSN:0007-1188
Publisher:Wiley (U.K.)
Volume:129
Number:8
Page Range:1537-1538
Date:1 April 2000
Official Publication:https://doi.org/10.1038/sj.bjp.0703239
PubMed:View item in PubMed

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