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New tools for the high throughput characterization of rat genomic DNA samples

Item Type:Article
Title:New tools for the high throughput characterization of rat genomic DNA samples
Creators Name:Knoblauch, M. and Goesele, C. and Zimdahl, H. and Hieke, B. and Himmelbauer, H. and Schalkwyk, L. and Lindpaintner, K. and Ganten, D. and Lehrach, H.
Abstract:Linkage studies and positional cloning projects for the identification of disease related genes require the genetic characterization of large numbers of genomic DNA samples. The application of spotting robots enables the production of high density filters representing several thousand DNA probes. To take full advantage of the potential of these filters we have established a new, hybridization based Interspersed Repetitive Sequence (IRS-)marker system for the rat genome. This marker panel was shown to be useful for rapid genotyping of many multigenic crosses as well as high throughput characterization of large insert genomic libraries.
Keywords:Chromosome Mapping, Genetic Markers
Source:Journal of Experimental Animal Science
ISSN:0939-8600
Publisher:Urban & Fischer Verlag (Germany)
Volume:41
Number:1-2
Page Range:35-37
Date:1 March 2000
Official Publication:https://doi.org/10.1016/S0939-8600(00)80024-3

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