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Interaction between Mas and the angiotensin AT1 receptor in the amygdala

Item Type:Article
Title:Interaction between Mas and the angiotensin AT1 receptor in the amygdala
Creators Name:Halbach, O.V.U. and Walther, T. and Bader, M. and Albrecht, D.
Abstract:The Mas-protooncogene is a maternally imprinted gene encoding an orphan G protein-coupled receptor expressed mainly in limbic structures of the rodent CNS. Because Mas and the product of the Mas-related gene enhance the effects of angiotensins on cells expressing angiotensin receptors of the AT1 subtype, we first compared the distribution of cells expressing AT1 receptors in different limbic and thalamic brain structures in Mas-knockout mice and in wildtype mice by an immunohistochemical approach. No significant differences could be found between the two strains. The Mas-protooncogene seems to be implicated in the signal transduction of angiotensin receptors and is expressed in the amygdala. Therefore we then analyzed whether field potentials are altered by angiotensin II in brain slices of the basolateral amygdala. An opposite action of angiotensin II was obtained in mice lacking the Mas-protooncogene in comparison to wildtype mice. The use of different angiotensin receptor antagonists provides the first in vitro evidence for a functional interaction between the Mas-protooncogene and the AT1 receptor.
Keywords:Action Potentials, Amygdala, Angiotensin II, Angiotensin Receptors, Antihypertensive Agents, Electrophysiology, G-Protein-Coupled Receptors, Immunoenzyme Techniques, Knockout Mice, Losartan, Proto-Oncogene Proteins, Saralasin, Type 1 Angiotensin Receptor, Type 2 Angiotensin Receptor, Vasoconstrictor Agents, Virus Receptors, Animals, Mice
Source:Journal of Neurophysiology
ISSN:0022-3077
Publisher:Amer Physiological Soc (U.S.A.)
Volume:83
Number:4
Page Range:2012-2021
Date:1 April 2000
Official Publication:http://jn.physiology.org/cgi/content/abstract/83/4/2012
PubMed:View item in PubMed

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