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Biochemical interactions in the wnt pathway

Item Type:Review
Title:Biochemical interactions in the wnt pathway
Creators Name:Seidensticker, M.J. and Behrens, J.
Abstract:The wnt signal transduction pathway is involved in many differentiation events during embryonic development and can lead to tumor formation after aberrant activation of its components. The cytoplasmic component {beta}-catenin is central to the transmission of wnt signals to the nucleus: in the absence of wnts {beta} catenin is constitutively degraded in proteasomes, whereas in the presence of wnts β-catenin is stabilized and associates with HMG box transcription factors of the LEF/TCF family. In tumors, {beta}-catenin degradation is blocked by mutations of the tumor suppressor gene APC (adenomatous polyposis coli), or of {beta}-catenin itself. As a consequence, constitutive TCF/{beta}-catenin complexes are formed and activate oncogenic target genes. This review discusses the mechanisms that silence the pathway in cells that do not receive a wnt signal and goes on to describe the regulatory steps involved in the activation of the pathway.
Keywords:{Beta}- Catenin, Adenomatous Polyposis Coli, Gene Expression, TCF Family, Tumor Development, Wnt Signal Transduction, Animals, Mice
Source:Biochimica et Biophysica Acta - Molecular Cell Research
ISSN:0167-4889
Publisher:Elsevier Science BV (The Netherlands)
Volume:1495
Number:2
Page Range:168-182
Date:2 February 2000
Official Publication:https://doi.org/10.1016/S0167-4889(99)00158-5
PubMed:View item in PubMed

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